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ea0099p116 | Pituitary and Neuroendocrinology | ECE2024

Cell lineage specific differences in clinical behavior of clinically non-functioning pituitary adenomas according to the 2017 WHO classification – a systematic review and meta-analysis

van der Hoeven Loren , Slagboom Tessa , Malekzadeh Arjan , Hoogmoed Jantien , Drent Madeleine , Aronica Eleonora , Jan Stenvers Dirk , Pereira Alberto

Background: In 2017, the World Health Organization (WHO) adjusted the histopathological classification of pituitary adenomas (PAs) by including pituitary cell lineage specific transcription factors (TFs), elucidating a continuous spectrum between true null cell (NCA), silent, clinically silent, and functioning adenomas. The definitions of non-functioning (silent) gonadotroph, corticotroph, somatolactotroph and thyrotroph adenomas were previously reserved for immunohistochemica...

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Cell lineage specific differences in clinical behavior of clinically non-functioning pituitary adenomas according to the 2017 WHO classification – a systematic review and meta-analysis

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